![]() ![]() Ĭonventional analyses of high-throughput expression data such as microarray data have long been focusing on the few most regulated genes, with the aim to correlate individual genes with a phenotype of interest. BubbleGUM is executable through an intuitive interface so that both bioinformaticians and biologists can use it. ![]() This innovative methodology has recently been used to answer important questions in functional genomics, such as the degree of similarities between microarray datasets from different laboratories or with different experimental models or clinical cohorts. Enrichments are displayed in a graphical output that helps interpreting the results. ConclusionsīubbleGUM is an open-source software that allows to automatically generate molecular signatures out of complex expression datasets and to assess directly their enrichment by GSEA on independent datasets. This analysis allowed us to confirm homologies between mouse and human immunocytes. We applied our method to generate transcriptomic fingerprints for murine cell types and to assess their enrichments in human cell types. ![]() One original feature of BubbleGUM notably resides in its capacity to integrate and compare numerous GSEA results into an easy-to-grasp graphical representation. We developed BubbleGUM (GSEA Unlimited Map), a tool that allows to automatically extract molecular signatures from transcriptomic data and perform exhaustive GSEA with multiple testing correction. Thus, there is a crucial need for an easy-to-use software for generation of relevant home-made gene sets from complex datasets, their use in GSEA, and the correction of the results when applied to multiple comparisons of many experimental conditions. This is all the more the case when attempting to define a gene set specific of one condition compared to many other ones. However, although many gene sets covering a large panel of biological fields are available in public databases, the ability to generate home-made gene sets relevant to one’s biological question is crucial but remains a substantial challenge to most biologists lacking statistic or bioinformatic expertise. This considerably improves extraction of information from high-throughput gene expression data. For example, the popular Gene Set Enrichment Analysis (GSEA) algorithm can detect moderate but coordinated expression changes of groups of presumably related genes between pairs of experimental conditions. Recent advances in the analysis of high-throughput expression data have led to the development of tools that scaled-up their focus from single-gene to gene set level. ![]()
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![]() ![]() The same options are offered for the seatback veneers, with the classy piano black on top. ![]() The coupe’s trunk capacity, which can accommodate two large trolley bags and smaller carry-on baggage, decreased due to the folding top, but the Brits have yet to release figures.Ĭustomization is possible through trim inlays, which include dyed open-ore Tamo ash, twill carbon-fiber satin, and satin chopped carbon-fiber. ![]() Tech includes Aston Martin’s latest infotainment system, a new satellite navigation system, a premium audio system, auto-park assist, a 360-degree camera, a tire pressure monitoring system, and keyless entry. These enable you to drive in comfort, while also providing proper support during spirited driving. The DBS also features the Nexus quilting and the Celestial perforation for the upholstery on the Sports Plus performance seats. As seen in the coupe, the DBS boasts the company’s finest leather, acres of Alcantara, and even carbon-fiber inlays. The C-pillars no longer extend toward the back and the rear window is smaller, which means that the Volante’s deck lid is longer. While some manufacturers design them to look like the metal-top of the coupe model, Aston Martin went with something different. Moving over to what sets the Volante apart, the soft-top has a slightly different shape. ![]() It also sports the louvered cutouts in the front fenders, the deeply sculpted side skirts, and beefy rear haunches. The V-shaped engine hood includes big vents, which give the car a race-inspired look.Īlthough it has a different windscreen and roof, both sitting lower than the coupe's, the Volante boasts the same muscular profile. Up front, the grand tourer is as aggressive as they get, featuring a massive honeycomb grille flanked by big air outlets, a protruding splitter, and slim headlamps with C-shaped LED design. The design is new and fresh and combines features seen on the DB11 with unique styling cues. The DBS Superleggera is decidedly different from the outgoing Vanquish. The DBS Superleggera Volante is obviously identical to the coupe below the waist. If there's anything you're unsure about, no matter how small, then please first ask the owner in the comments area below before placing your bid/s, as bids can't be retracted and form a binding contract if you win the car - just like a traditional auction house.Before_label=2020 Aston Martin DBS Superleggera VolanteĪfter_label=2020 Aston Martin DBS Superleggera Coupe> Viewings are also welcomed with all our listings, so please get in touch with us to arrange a suitable time - we just need to speak to you first and receive a valid photo ID before confirming. So please sit back, have a cuppa and take your time to review everything on this listing in order to make your own assessment on the vehicle's condition. We've summarised our own view on the car based on information gained from the seller in the listing above, however, and as you can see, we go to great lengths to photograph and video the car in hi-resolution detail - this has been done for you to make your own assessment from the comfort of your sofa. We’ve done all our usual seller checks including photo ID, V5 and also actioned a HPi check on the vehicle. Andrew will be happy to answer any questions you may have about the car in the comments below. Coming with a comprehensive service with the Aston Martin agents in Singapore, and then service by the main dealers here upon import, this low mileage DBS Volante presents in excellent condition. ![]() ![]() There is no need to continuously purchase more torches when you run out of juice. Run out of butane in your device? No need to fret! Scorch torches have a section where you can easily insert a bottle of butane and refill your device. Depending on how much heat you want, you can turn that knob to increase or decrease the amount of flame that is coming from your torch. Here are some of the features that you should expect to see in a torch lighter.Ī scorch torch lighter will usually have a knob that you can turn in order to control the amount of butane that is being released from your device. Overall, scorch lighters are produced with ease-of-use and safety in mind. The buttons featured on these devices are very simple to use and let you operate your torch easily. Scorch torches are built with lightweight metals and ergonomic grips. This helps you better grip your device and protect you from the intense heat that it produces. ![]() A quad torch lighter comes with four jet flames rather than a single one which most of them do. The jet flame can be a single, dual or quad flame. Scorch torch can come in very different models and designs. ![]() Heating up your dab tools can take a bit longer but using a cigar torch lighter can help. ![]() Offering a powerful torch flame, heat up anything from a cigarette and cigar to your dab rig. If lighting up is a part of your life, a Scorch Torch lighter is a necessity. If you are seeking a better smoking experience, a scorch torch is a must need tool for smoking. However, other materials may require a more consistent and hotter flame in order to get the right heat. If you’re an avid user of water pipes, you are probably used to using a lighter to begin your smoking sessions. ![]() ![]() ![]() ![]() Create a file called concat.txt and add the following entries (corresponding to the video clips created above): file 'part1.mp4' You can in principle also try to concatenate the bitstreams without re-encoding them, using the concat demuxer. It’s a little more straightforward but otherwise should be equivalent to the above method. This will again re-encode the video stream. If the files have audio, use the same approach as above: ffmpeg -i part1.mp4 -i short-video.mp4 -i part3.mp4 -filter_complex \ If you want to split the clips and later reassemble them:įfmpeg -i edv_g24.mp4 -ss 0 -to 10 -c copy part1.mp4įfmpeg -i edv_g24.mp4 -ss 10 -to 15 -c copy part2.mp4įfmpeg -i edv_g24.mp4 -ss 15 -c copy part3.mp4įfmpeg -i part1.mp4 -i short-video.mp4 -i part3.mp4 -filter_complex \ You can read more about this on the FFmpeg Wiki, e.g. Note that video and audio will be re-encoded in this case – make sure to specify appropriate output quality targets (e.g. If your files have audio, you have to trim those streams separately: ffmpeg -i edv_g24_2.mp4 -i short-video.mp4 -filter_complex "\Ītrim=0:10,asetpts=PTS-STARTPTS \Ītrim=0:5,asetpts=PTS-STARTPTS \Ītrim=15:30,asetpts=PTS-STARTPTS \Ĭoncat=n=3:v=1:a=1" \ If you want to trim from a certain timestamp to the end, use trim=start=15 instead of specifying the range. ![]() (The setpts filter resets the timestamps of these individual parts to 0, which is required for concatenation). Here, trim is used to specify the individual portions of the input video streams ( 0:v, 1:v) that you later want to concatenate. Is there any ways to force the header size also (aside from codecs) be the same?įfmpeg -i edv_g24.mp4 -i short-video.mp4 -filter_complex "\ I noticed the HEADER SIZE is different which is apparently causing the problem. I used mediainfo tool to compare the two files and noticed differences in the header sizes while all video codec related stuff was the same. Second question: Assuming FFmpeg is the viable solution, when I simply use the command ffmpeg -I -ss 10 -t 5 -c copy output.mp4, my video processing code can not read and process the file. First split the video (in this case, 0-10, 10-15, and 15-end)įirst question: Is this the best and fastest solution? Do we have an easier command or other tools to replace a specific period of time in video with another video?.For instance, for input 10 15 I will need to replace EXACT seconds 10 to 15 with another video. I’m trying to use FFmpeg to split video based on some start_time and end_time inputs, and replace those with other video files. ![]() ![]() ![]() Broken Social Scene – Me And My Hand – 2:05 (740 kbps, 11.Broken Social Scene – Water In Hell – 4:25 (1000 kbps, 31.6 MB).Broken Social Scene – Romance To The Grave – 4:48 (837 kbps, 28.71 MB).Broken Social Scene – Sweetest Kill – 5:09 (758 kbps, 27.93 MB).Broken Social Scene – Sentimental X’s – 5:40 (778 kbps, 31.59 MB) Words: 10th May 2017, It’s been seven years since Canadian collective Broken Social Scene released their last album, ‘Forgiveness Rock Record. ![]()
![]() ![]() '/Users/quixote/dev/tilt-avatars/api/app.py' -> '/app/api/app.py' In practice, that results in what we saw in the “api” logs in Tilt: Will copy 1 file(s) to container: 4a9aac5527 □♀️ Files you sync to the container must match paths that Tilt is already watching for the image configuration The destination path ( /app/api/) is the absolute path inside the container where we want the files copied to. api/) is the path, relative to the Tiltfile, on our machine that we want Tilt to watch for changes to (recursively). To understand what happened, let’s take a look at the docker_build configuration for the tilt-avatar-api image: Dress the character with some stylish glasses (this is important!!! □).Watch magic happen for the api resource in the Tilt UI.Find the commented out line # 'other':.Open api/app.py in your favorite editor.It works with frameworks that natively support hot reload (e.g. Live Update solves these challenges by performing an in-place update of the containers in your cluster. Wait for roll out of new Pods using the updated image (open Reddit, □, etc.).Update the tag in YAML and apply the the Deployment to the cluster ( kubectl apply -f. ![]() Pushed the built image to a registry ( docker push.Rebuilding the container image ( docker build.Tilt’s deep understanding of your resources means the right things get rebuilt at the right times.Įven with Docker layer caching, rebuilding a container image can be slow.įor unoptimized Kubernetes-based development, every code change requires: Smart Rebuilds with Live Update Tilt Tutorial ![]() ![]() ![]() Software Affected?- Determine if the software version(s) in use are affected by the vulnerabilities described within the Smart Install Security Advisories.Identification & Mitigation StepsĬustomers concerned with potential exposure of their network devices to the Smart Install vulnerabilities should adhere to the following process: Additionally, patches for known security vulnerabilities should be applied as part of standard network security management. ![]() Customers who do use the feature – and need to leave it enabled – can use ACLs to block incoming traffic on TCP port 4786 (the proper security control). To ensure their network is protected against issues involving Smart Install, our recommendation for customers not actually using Smart Install is to disable the feature using the no vstack command once setup is complete. Reload, denial of service, remote code executionĬisco IOS and IOS XE Software Smart Install Denial of Service VulnerabilityĬisco IOS and IOS XE Software Smart Install Memory Leak VulnerabilityĬisco IOS Software Smart Install Denial of Service VulnerabilityĬisco IOS Software Smart Install Remote Code Execution Vulnerability Widespread scanning for devices with the Smart Install feature enabled and without proper security controlsĬisco IOS and IOS XE Software Smart Install Remote Code Execution Vulnerability The following table lists the Advisories that identify the Smart Install feature (Client and/or Director) as being vulnerable and the extent that these respective vulnerabilities are being actively exploited: ![]() ![]() ![]() The new mGuard rs2000 portfolio positions itself as a low-priced field equipment line for secure remote maintenance scenarios. Due to its front-side configuration memory (SD card), the mGuard rs2000 can be quickly and easily put into operation, updated and exchanged. The inexpensive new industrial remote services router generation mGuard rs2000 from Innominate's field line convinces with its secure transmission paths and simple operation in compact, DIN rail-mountable industrial metal casing. You can help by choosing one of the links below to provide feedback about this product.Industrial VPN router for field installations BACKGROUNDĬritical Infrastructure Sectors: Communications, Critical Manufacturing, Information Technologyįor any questions related to this report, please contact the CISA at:įor industrial control systems cybersecurity information: ĬISA continuously strives to improve its products and services. coordinated this vulnerability with NCCIC. PHOENIX CONTACT reported to that their products are affected. A CVSS v3 base score of 7.8 has been assigned the CVSS vector string is ( AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H). Verification may not always be performed correctly, allowing an attacker to modify firmware update packages.ĬVE-2018-5441 has been assigned to this vulnerability. MGuard devices rely on internal checksums for verification of the internal integrity of the update packages. IMPROPER VALIDATION OF INTEGRITY CHECK VALUE CWE-354 This vulnerability is not remotely exploitable. No known public exploits specifically target this vulnerability. Organizations observing any suspected malicious activity should follow their established internal procedures and report their findings to NCCIC for tracking and correlation against other incidents. Several recommended practices are available for reading and download, including Improving Industrial Control Systems Cybersecurity with Defense-in-Depth Strategies.Īdditional mitigation guidance and recommended practices are publicly available in the NCCIC Technical Information Paper, ICS-TIP-12-146-01B-Targeted Cyber Intrusion Detection and Mitigation Strategies, that is available for download from the ICS-CERT web site. NCCIC also provides a section for control systems security recommended practices on the ICS-CERT web page. NCCIC reminds organizations to perform proper impact analysis and risk assessment prior to deploying defensive measures. Also recognize that VPN is only as secure as the connected devices. When remote access is required, use secure methods, such as Virtual Private Networks (VPNs), recognizing that VPNs may have vulnerabilities and should be updated to the most current version available.Locate control system networks and remote devices behind firewalls, and isolate them from the business network.Minimize network exposure for all control system devices and/or systems, and ensure that they are not accessible from the Internet.NCCIC recommends users take defensive measures to minimize the risk of exploitation of these vulnerabilities. PHOENIX CONTACT recommends that affected users upgrade to firmware version 8.6.1 Successful exploitation of this vulnerability could allow for an attacker to modify firmware update packages. The following versions of mGuard, a network device, are affected: Vulnerability: Improper Validation of Integrity Check Value AFFECTED PRODUCTS ![]() ![]() ![]() Remember – you can always use Lumen5 to create stunning videos with just a few clicks. We here at Bleacher Report understand that, and have compiled a bunch of our favorite. Now that you’ve downloaded your favorite video(s), it’s time to spice them up and make them your own assets. Sometimes, you just need a break from the hustle and bustle to watch some amusing football videos on YouTube. The reason why YouTube discourages downloading is to protect its users and retain them on their platform. Mackenzie Hughes of Canada shot the low round of the day, a 9-under-par 63, to vault into a tie for the lead at the Sanderson Farms Championship on Friday.
![]() ![]() But with the increased isolation brought on by the pandemic, I grew tired of swiping, ghosting, catfishing and no commitment. So initially, I was drawn to online dating. I'm much more suited to striking up a conversation with a stranger on my smartphone than I am in the real world. And as a millennial, I find it harder to date offline. (Ironically, if you are an unmarried Indian man in your 30s or maybe early 40s, you're still a catch.)ĭating is hard. But none of that changes my culture's valuation of a woman in my position - if you are an Indian girl unmarried in her 30s, you are fast approaching the status of an old maid. I can assemble IKEA furniture and even change a flat tire. I pay my own bills and I have my own house. I live in Toronto, work in television and am a stand-up comic. Pooja Joshi, seen as a baby, has grown up on a steady diet of Hollywood and Bollywood romcoms. Their child typically can then exercise "veto" power. But now it's more like a dating service enabled by families who pre-select "suitable" partners. In previous generations, the parents picked the partner. It's a common way to get married in the South Asian community - where parents find a prospective groom or bride for their adult children. ![]() If it were up to my family, I would have already married as my parents did: in an arranged match. They're expecting babies, while I'm still inspecting dating profiles. My younger cousins are all wed and seemingly happily so. In my culture, I am late to board the marriage train. But for my Indian family, alarm bells are ringing. I am 34 and still single which is no big deal for many people. For more information about CBC's First Person stories, please see the FAQ. She currently works as a producer for CBC Radio's The Debaters. This First Person column is written by Pooja Joshi, a first-generation Indian Canadian. ![]() |
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